اعلام University of Babylon | Master’s Thesis at the University of Babylon on Skin Damage Caused by Ultraviolet Radiation

اعلام University of Babylon - كلية الادارة والاقتصاد

Master’s Thesis at the University of Babylon on Skin Damage Caused by Ultraviolet Radiation

By : Zaynab Kadhim Ameen Awadh

Date : 31/8/2025 24:09:11 AM

Master’s Thesis at the University of Babylon on Skin Damage Caused by Ultraviolet Radiation
The College of Medicine, University of Babylon, Department of Pharmacology and Toxicology, discussed the master’s thesis of student Zahraa Abdul Kareem Ajmi, titled “Evaluation of the Anti-inflammatory and Sunscreen Effects of Topical Tranexamic Acid and Zinc Oxide on Ultraviolet B-induced Skin Damage in an Animal Model”, supervised by Assistant Professor Majid Kazem Abbas and Professor Wissam Ali Ameen.
The defense session was attended by the head of the department, Assistant Professor Dr. Riyadh Hashem Al-Moussawi, along with a number of faculty members and postgraduate students.
During her defense, the researcher explained that skin erythema is the most prominent feature of ultraviolet (UV) radiation on the skin. It appears as noticeable redness caused by increased blood volume in the superficial and deep blood vessels for at least 6 hours after UV exposure. This marked vasodilation can lead to edema formation and leukocyte infiltration as part of the inflammatory response. Currently, many studies have reported that exposure to UV radiation, particularly UVB, can increase local blood flow.
Ultraviolet radiation consists of three components: UVA (320–400 nm), UVB (280–320 nm), and UVC (100–280 nm). Unlike UVA and UVB, UVC is almost completely absorbed by the ozone layer. The rays that reach the earth are sufficient to damage skin structure. The harmful effects of ultraviolet radiation include erythema (sunburn), eye problems (such as cataracts and pterygium), skin aging, skin cancer, and immune suppression.
The aim of this study was to clarify the anti-inflammatory effect of tranexamic acid (TXA) and zinc oxide on UVB-induced erythema, and to investigate the effect of using different concentrations of tranexamic acid.
Fifty rats were divided into five groups, each consisting of ten animals:
• Group A: Normal control group.
• Group B: UVB-induced erythema group (received UVB only).
• Group C: Treated with zinc oxide and exposed to UVB, four times per week on alternate days.
• Group D: Treated with 10% TXA and exposed to UVB, four times per week on alternate days.
• Group E: Treated with 5% TXA serum and exposed to UVB, four times per week on alternate days.
In conclusion, the study demonstrated that tranexamic acid and zinc oxide reduce inflammation and oxidative stress associated with UVB-induced erythema by decreasing inflammatory mediators and oxidative stress markers.